![]() ![]() Below, an easy guide to how to organize your photos. An umbrella term for the cities of Palm Beach County, the region includes spots like West Palm Beach, Palm Beach. You’ll appreciate them so much more once you’ve swapped your JPGs for keepsakes. Think of the Palm Beaches as a fast pass to the best of Florida. ![]() It also works for photos snapped on rides such as roller coasters. ![]() Fun Vacation stock photos are available in a variety of sizes and formats to fit your needs. How to have an awesome family vacation at Disney or elsewhere at an affordable price. So what better time to put them in order? Once you've pared down your camera roll, you can showcase your memories in an engraved leather scrapbook, sleek hanging frames, glossy printed photo books, or a digital picture frame. Browse Getty Images' premium collection of high-quality, authentic Fun Vacation stock photos, royalty-free images, and pictures. But the situation also presents an opportunity to reflect on the experiences we’re fresh off of, through the photos we've taken. Right now, many of us remain house-bound, with our formerly busy lives on pause. Really important things are not that great in number.” (For this reason, I'm now shooting fewer, more intentional shots on film and am laying off of digital for a while.) She writes: “With this method, you will keep only about five per day of a special trip, but this will be so representative of that time that they bring back the rest vividly. Snow-capped peaks, alpine meadows and azure lakes are just a few reasons why Glacier National Park is one of America's most. She recommends consolidating pictures by examining them one by one, so that you can process each photo individually while identifying the few keepers. 3 in World's Best Places to Visit for 2023. Marie Kondo addresses this conundrum in her book, The Life-Changing Magic of Tidying Up. ![]()
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![]() PC or Computer with operating systems such as Windows 7, 8, 8.1, 10 and Mac. The first versions weren't exactly fantastic, until Solitaire Windows XP was brought onto the market and, according to seasoned players, this is still the best version of the game to this day. Step by step instructions to download and install My Vegas Solitaire Cards. If you’re able to play that card, you can then play the next card of the two that are remaining, and if you can do that, you can. This is a more difficult version of the game since you can only play every third card from the stockpile. You may also like FreeCell, which has four open cells you can place cards in, and is most similar to solving a puzzle with a deck of cards. Description: Solitaire has been around for centuries, but only became truly popular when Microsoft brought it onto the market in the 1990s. Play Solitaire Turn 3 online - for free Play solitaire where 3 cards are drawn from the stockpile at once. If you like the challenge and luck elements of Vegas Solitaire, you'll also like Spider Solitaire, which requires you two move two decks of cards into the foundation. With the wrong draw, you may not get enough cards to the the foundation in time to earn your coins back. Vegas Solitaire can be a challenging game, and much of it depends on luck. Pyramid Solitaire - Classic Free Card Games. This means you can only go through the stock pile once, making the game more difficult than traditional Klondike Solitaire. If you're looking for a challenge, Vegas Solitaire only allows for one turn through the deck. If you run out of coins, don't worry - each day we refill your total with another 200 coins! You can also review our strategy guide to help you make the best moves. ![]() You are only allowed 1 pass through the deck.It is more commonly played on a computer, than as a physical. ![]() Mahjong solitaire is a single-player matching game that uses a set of mahjong tiles rather than playing cards. Start with 350 solitaire chips to play as long as you want. The most popular card solitaire is Klondike, which was called Microsoft Solitaire in a digital implementation included with the Windows operating system from 1990 onwards. Earn 5 for every card you move to the foundation. This premium solitaire game comes with incredible card game and solataire features: Play Classic Solitaire gameplay with a Vegas Twist. ![]() In the Las Vegas version, you wager coins to play, and earn them back as you proceed through the game: The rules are similar to standard Solitaire (also known as Klondike). ![]() ![]() ![]() Do you know of another open source tool that provides this functionality on Linux? Please share your favorite in the comments. Version 2.1.5 is out now screenfetch now supports detecting multiple monitors resolutions and a couple more WMs. ![]() No matter why you want to share your system configuration, screenFetch or Neofetch should enable you to do so. If Neofetch doesn't support your operating system or provide all the options you are looking for, be sure to open up an issue in the project's GitHub repo. The nf file also makes it easy to share your customization with others. Screenfetch is a script with nearly 6,500 lines. For example, you can configure Neofetch to use the image, ASCII file, or wallpaper of your choice-or nothing at all. config/nf), which enables you to customize and control every aspect of Neofetch's output. On its first run, Neofetch writes a ~/.config/neofetch/ nf file to your home directory (. On Ubuntu 17.10 and greater, you can use: $ sudo apt install neofetch If you are on Fedora, RHEL, or CentOS, you can install Neofetch at the Bash prompt with: $ sudo dnf install neofetch The project maintains a wiki with excellent installation documentation for a variety of distributions and operating systems. Once screenFetch is installed, it can produce a detailed and colorful screenshot like this: S screenfetch Project information Project information Activity Members Repository Repository Files Commits Branches Tags Contributor statistics. ![]() On Ubuntu, enter: $ sudo apt install screenfetchįor other operating systems, including FreeBSD, MacOS, and more, consult the screenFetch wiki's installation page. On Fedora, enter: $ sudo dnf install screenfetch It's simple to install screenFetch for many Linux distributions. It is an easy way to share your system's configuration with others in a colorful way. ScreenFetch is a Bash command-line utility that can produce a very nice screenshot of your system configuration and uptime. But if you want to share more details, such as your operating system, kernel, uptime, shell environment, screen resolution, etc., you have two great tools to choose: screenFetch and Neofetch. You could get some of that information with a cat /proc/cpuinfo or lscpu command at the Bash prompt. For example, I dont like to see Memory I prefer to change it to RAM.
![]() ![]() (Image credit: Bitdefender) Bitdefender Total Security: Password Managerīitdefender Antivirus Plus, Internet Security and Total Security all include Wallets, the same password manager they’ve had for years. It even prevents leaks via the clipboard: whatever you paste into the clipboard from Safepay, it can't be viewed from any other process. Our custom keylogger wasn't able to record Safekey keypresses via the device or virtual keyboard. Screen capture tools couldn't 'see' Safepay's screen. Our tests showed Safepay works very well. There's also a simple virtual keyboard where you can enter text using your mouse rather than typing, helping to protect you from even hardware keyloggers. ![]() A built-in pop-up blocker keeps some browsing dangers at bay. Safepay doesn't support third-party extensions as they'd be a security risk, but it integrates with Bitdefender's password manager, handy for avoiding the need to remember your banking and e-store credentials. We’re not just talking about external attacks: it also tries to prevent malicious apps running on your own system from monitoring your web usage. (Image credit: Bitdefender) Bitdefender Total Security: Safepayīitdefender Safepay is a secure browser which aims to protect your online banking, shopping and other activities from snoopers. It's easy to use, with a decent set of features on Windows (ad and tracker blocking, split tunneling, more). Still, if you can live within the tight data limits, Bitdefender VPN isn't a bad service. This could still be enough to cover the bare essentials, maybe checking your email or accessing work resources a few times a day over public Wi-Fi, but not much else. The results will vary hugely depending on the sites you visit and how you use them, but our meter ran out after around 30 minutes. We turned on the VPN and browsed eBay, Amazon and a few news sites to get a feel for how long this might last. This is sort-of true, but there's a very big catch: you only get the limited version of the VPN, which doesn't allow you to choose a location (it automatically connects to the faster server only), and protects only 200MB of traffic a day. It protects your online presence by encrypting all Internet traffic.' (Image credit: Bitdefender) Bitdefender Total Security: Limited VPNĪll Bitdefender security tools from Antivirus Plus up include the company's VPN, and the website is keen to spell out the advantages: 'With Bitdefender VPN, you can stop worrying about privacy on the web. That’s fractionally behind G Data (9.98), Kaspersky (9.98), McAfee (9.96), Norton (9.96) and Avast (9.95), though ahead of names like Avira (9.93), ESET (9.90) and Trend Micro (9.68). Bitdefender achieved 9.94 in our own rankings, a decent 6th place out of 15. To make sense of all these results, we created a system which combined them into a single overall score between zero and ten. We didn’t see this on our test PC, but it could be an issue if you’ll be running the app on underpowered hardware. There’s one notable exception, with AV-Comparatives and PassMark finding that Bitdefender had more impact on system speed than average. Other results have better news, with AV-Test’s Windows Home User, SE Labs Home User Endpoint Security, and MRG Effitas last 360° Assessment report all detailing 100% protection in at least one of their antivirus tests. It actually blocked 624 out of 626 test threats, a pretty decent result, but this time Avast and G Data happened to block 626, earning them first place. Some recent results show Bitdefender’s rankings dropping just a little, but it’s a mixed picture, and the company still performs well above average overall.īitdefender ranks equal 6th out of 17 in AV-Comparatives’ Real-World Protection test, but the positions are based on tiny differences. But Bitdefender only checks new and changed files, which ensures they become much faster from the second run.īitdefender products are regularly assessed by all the big independent antivirus testing labs. If that’s not enough, you’re also able to configure and schedule scans, or check files, folders or drives on demand. ![]() Read our Bitdefender Internet Security review for a more detailed look.īitdefender’s antivirus protection begins with automatic scanning of downloads and apps for malware. (Image credit: Bitdefender) Bitdefender Total Security: Antivirusīitdefender Total Security’s Windows app is absolutely stuffed with antivirus and other features, but as they’re identical to Bitdefender Security - and there’s much, much more to talk about - we’ll only summarize them here. ![]() ![]() ![]() If you have created a system restore point prior to installing a program, then you can use System Restore to restore your system and completely eradicate the unwanted programs like ZMatrix 1.5.2. System Restore is a utility which comes with Windows operating systems and helps computer users restore the system to a previous state and remove programs interfering with the operation of the computer. Method 3: Uninstall ZMatrix 1.5.2 via System Restore. Double click on its uninstaller and follow the wizard to uninstall ZMatrix 1.5.2. ![]() Go to the installation folder of ZMatrix 1.5.2. You can find this files in the installation folder of ZMatrix 1.5.2. Most of computer programs have an executable file named uninst000.exe or uninstall.exe or something along these lines. Method 2: Uninstall ZMatrix 1.5.2 with its uninstaller.exe. Look for ZMatrix 1.5.2 in the list, click on it and then click Uninstall to initiate the uninstallation. Open WinX menu by holding Windows and X keys together, and then click Programs and Features.ī. So when you want to uninstall ZMatrix 1.5.2, the first solution is to uninstall it via Programs and Features.Ĭlick Start, type uninstall a program in the Search programs and files box and then click the result. When you want to uninstall the program, you can go to the Programs and Features to uninstall it. When a new piece of program is installed on your system, that program is added to the list in Programs and Features. Method 1: Uninstall ZMatrix 1.5.2 via Programs and Features. Method 7: Uninstall ZMatrix 1.5.2 with Third-party Uninstaller. ![]() Method 6: Use the Uninstall Command Displayed in the Registry. Method 5: Reinstall ZMatrix 1.5.2 to uninstall. Method 4: Uninstall ZMatrix 1.5.2 with Antivirus. Recommended Method: Quick Way to Uninstall ZMatrix 1.5.2 Method 1: Uninstall ZMatrix 1.5.2 via Programs and Features. How to Uninstall ZMatrix 1.5.2 Completley? So, it's really important to completely uninstall ZMatrix 1.5.2 and remove all of its files. An incomplete uninstallation of ZMatrix 1.5.2 may also cause many problems. ZMatrix 1.5.2 cannot be uninstalled due to many other problems. * Files and folders of ZMatrix 1.5.2 can be found in the hard disk after the uninstallation. * Another process that is using the file stops ZMatrix 1.5.2 being uninstalled. Not all of the files were successfully uninstalled. * A file required for this uninstallation to complete could not be run. ![]() * You do not have sufficient access to uninstall ZMatrix 1.5.2. * ZMatrix 1.5.2 is not listed in Programs and Features. Possible problems when you uninstall ZMatrix 1.5.2 Also, since Z-matrices can contain molecular connectivity information (but do not always contain this information), quantum chemical calculations such as geometry optimization may be performed faster, because an educated guess is available for an initial Hessian matrix, and more natural internal coordinates are used rather than Cartesian coordinates.Are you in need of uninstalling ZMatrix 1.5.2 to fix some problems? Are you looking for an effective solution to completely uninstall it and thoroughly delete all of its files out of your PC? No worry! This page provides detailed instructions on how to completely uninstall ZMatrix 1.5.2. A skillful choice of internal coordinates can make the interpretation of results straightforward. They are used for creating input geometries for molecular systems in many molecular modelling and computational chemistry programs. Z-matrices can be converted to cartesian coordinates and back, the information content is identical. Recognize and detect the effects of electrostatic charges on your balance ![]() ![]() ![]() Dragon Ball Goku illustration, Goku Vegeta Dragon Ball Saiyan Super Saiya, superheroes, orange, poster, logo png 570x708px 22.24KB.elephant, zebra, monkey, giraffe, and lion, Safari Elephant, safari, mammal, food, cat Like Mammal png 660x550px 790.74KB.Marvel baby Groot artwork, Baby Groot Decal Bumper sticker, rocket raccoon, white, face, fictional Characters png 500x882px 105.3KB.pool party, Party Sticker Birthday Convite, party, holidays, text, label png 600x512px 138.06KB.brown bear illustration, Prince Bear Baby shower Party Child, bear, mammal, cat Like Mammal, animals png 1319x1600px 242.11KB. ![]() Birthday Party Cartoon, pocoyo, boy holding balloons, television, holidays, computer Wallpaper png 500圆00px 195.99KB.Daddy Pig Princess Peppa, PEPPA PIG, Peppa Pig, child, animals, poster png 794x900px 66.87KB.Animal Jungle, Giraffe elephant zebra lion, zoo animals illustration, animals, leaf, fauna png 1146x1066px 547.47KB.camera, multicolored DSLR camera illustration, watercolor Painting, blue, camera Lens png 1899x2211px 1.22MB.Baby Jungle Animals, farm animals, animals on top of table illustration, comics, mammal, carnivoran png 3000x1772px 1.46MB.black paw, Dog Puppy Paw Cat, paw prints, animals, pet, paw png 4106x3765px 40.95KB.1 2 3 4 5 text overlay, Chart, Creative PPT element, angle, 3D Computer Graphics, text png 523x1040px 105.21KB.Wildcat Dog Paw, finger print, animals, sticker, black png 4106x3765px 40.91KB.graphy illustration, Girl cycling, couple sketch illustration, love, angle, white png 919x1000px 180.43KB.tiger illustration, Baby Tigers Infant Baby shower, safari, mammal, child, cat Like Mammal png 774x900px 87.78KB.Moana Birthday Party Child The Walt Disney Company, baby, baby Moana illustration, holidays, baby, people png 1461x1689px 1.8MB.boy wearing safari outfit illustration, Safari Drawing Baby Zebras, safari, hat, toddler, boy png 583x900px 85.86KB.Giraffe Wall decal Jungle Animals Appliqué, jungle safari, mammal, textile, giraffe png 477x800px 62.54KB.Diaper Infant Baby shower Elephant, safari, gray elephant illustration, mammal, child, carnivoran png 1024x1024px 61.59KB.Party hat, Cartoon Unicorn, Cute Unicorn, Baby Unicorn, Sticker, Cartoon Unicorn, Cute Unicorn, Baby Unicorn png 1000x1000px 698.72KB.Minnie Mouse, Minnie Mouse Mickey Mouse The Walt Disney Company, baby minnie mouse, 3D Computer Graphics, color, sticker png 493x985px 490.77KB.zebra illustration, Baby Jungle Animals Infant, safari, white, mammal, cat Like Mammal png 600x512px 84.14KB.Lion Infant Baby shower Child, safari, lion sticker, mammal, cat Like Mammal, animals png 1600x1534px 151.16KB.Dog Logo Paw Patrol, paw patrol, Paw Patrol logo, emblem, animals, paw png 1023x887px 400.41KB.Use our tiger, panther, tree, river, snake, zebra, ant, canopy, large leaf, and lagoon icon, then communicate your jungle-friendly brand to animal-lover, nature-lover clients, customers, audience, and investors. Try customizing these with a few simple clicks, changing the shape, size, font, style, and layout. On BrandCrowd, you’ll get these essential images too: business cards, email signatures, invoices, invitations, menus, flyers, and many others. Explore these logo ideas so you have the perfect logos for your unique brand identity. Our logo generator houses tens to thousands of logo designs and dozens of specific themes. Make your brand more wild and forest-y using the jungle logo collection. Wordmarks and font-based logos present leopard and zebra prints and many others. Take tree images, animal prints, leaf icons, river pictures, mountain emblems, and more. Want some green aesthetics incorporated into your brand? Try our Jungle logo maker and get your very own jungle-inspired logo. ![]() ![]() ![]() Finally, on February 1, 2018, Waterfox 56.0.4 was released with these patches. Three days later, the Waterfox project said it had been performing on integrating these patches on Twitter. Here’s a newer example from a minor release: On January 23, 2018, Mozilla released Firefox 58 and Firefox ESR 52.6 with a spread of security fixes. ![]() We don’t think waiting quite a fortnight for security updates may be a good idea! Waterfox’s developers released Waterfox 56 that incorporated the safety updates found in Firefox 57 on November 30, 2017. So whenever Mozilla releases security updates for Firefox ESR, the Waterfox developers need to integrate those updates into Waterfox before delivering them to users.Ĭheck out the initial major release: Mozilla released Firefox 57 on November 14, 2017. Overall, using Waterfox is essentially a bit like using Firefox ESR and changing a couple of settings…with one big difference: security updates arrive in Firefox ESR much faster than they do in Waterfox. Finally, encrypted Media Extensions (EME), which are required for sites like Netflix, also are disabled by default-and, again, you’ll disable them yourself in Firefox, if you wish. ![]() Likewise, it won’t send telemetry data to Mozilla, but you’ll disable that from Options > Privacy & Security > Firefox Data Collection and Use in Firefox. It disables Pocket by default, but you’ll disable Pocket yourself in Firefox. Waterfox also has another different feature. But, after taking some deserved public heat, they’ve made policy changes, and we’re hopeful they’ll do better within the future. Robot “Looking Glass” add-on was ridiculous, and we’re not thrilled about what they’re doing with Cliqz in Germany. Yes, Mozilla has done some things we’re not crazy about. However, if you would like to stay using your old add-ons that do not add Firefox Quantum, we recommend Mozilla’s Firefox Extended Support Release (ESR) instead.įirefox ESR is predicated on Firefox 52, supports traditional XUL Firefox add-ons and NPAPI plug-ins, and can continue receiving security updates directly from Mozilla until July 2, 2018. We like Firefox Quantum, which is quicker and more modern than previous releases of Firefox. If You Don’t Like Firefox Quantum, Use Firefox ESR Instead But we recommend against using any of them. That’s what Waterfox, Pale Moon, and Basilisk are-alternative browsers supported the Firefox code. Mozilla Firefox is an open-source project, so anyone can take its code, modify it, and release a replacement browser. Here we can see, “Why You Shouldn’t Use Firefox Forks Like Waterfox, Pale Moon, or Basilisk” ![]() ![]() Using command with the left arrow key will move it to the beginning of the current line, while using it with the right arrow key will move it to the end of the current line. While working in text, use the command key with one of the arrow keys to move the cursor to different parts of a document. This shortcut operates as a “redo” functionality to put back the last change that was undone with an “undo” function. ![]() While fairly common, this shortcut is an important one. Modify as Command + Option + H to hide windows of other applications that are running. Hide the windows of the application that is currently running. This shortcut will find text in a document, using a search bar functionality. SEE: Top 20 Apple keyboard shortcuts for business users (free PDF) (TechRepublic) Modify this as Command + Colon (Shift + Semicolon) to open the spelling and grammar window. By holding command and continuously hitting the semicolon ( ) it will cycle through the misspelled words. Use this shortcut to find all misspelled words in a given document. If you modify it as Command + Shift + Control + 4, it will save it to the clipboard. If you want to screenshot a selection from your screen, this shortcut will give you the option to select what you want in a box and save it as a file on your desktop. If you modify it as Command + Shift + Control + 3, it will save it to the clipboard. If you need to quickly take a screenshot of your full screen, this shortcut will do that, and save it as a file on your desktop. This is the shortcut for “Paste and Match Style,” which basically means you can copy and paste something without its previous formatting. This shortcut is a life-saver for anyone who regularly works in Safari. Simply put the folder path in the space the appears and it will take you directly to the folder.īy pressing “command” and the left bracket () you can move to the next folder. When you have a finder window open, use this shortcut to open a direct line to a specific folder. If you use multiple displays this will be especially helpful, as this combination immediately puts all displays to sleep. This is a great tool to help you quickly get to a buried file or folder. This shortcut simply opens the spotlight search and moves your cursor into the search bar. ![]() Each time you press tab, it will switch to the next application in line. Start by holding down the “command” key and pressing “tab” to cycle through applications. This key combination will allow you to cycle through open applications. Hopefully these tips will make you a more productive user of your Apple machine at work. Here are Mac keyboard shortcuts that will improve your workflow. SEE: 31 Mac keyboard shortcuts business users need to know (free PDF) (TechRepublic) There are the old standards, such as cut and paste, but you can take it so much further. ![]() The proper shortcuts can turn your keyboard from a writing tool into a command center for your computer.įor Apple users, the proprietary keys can be daunting at first, but they offer a host of great shortcuts to make your workday easier. One of the most useful tools in the quest for productivity in office work is the use of keyboard shortcuts. ![]() ![]() Not surprisingly, Eley’s 38-grain load posted a best group of. Incredibly quiet and lethal, Eley’s Subsonic Hollow load delivers hunting performance with match-grade accuracy. of energy still ensures lethal expansion and penetration on varmint-sized critters while a nongreasy lubricant coating provides flawless operation in semiauto platforms and varied weather conditions. 22 LR load features a 38-grain hollowpoint bullet that’s designed to expand at a lower velocity of 1,037 fps. Let’s just say the company knows its way to the top of the podium. Known for its competition pedigree and precision loading, Eley has long been a top performer and producer of. Reliable, accurate and cost effective, it’s also designed to run in semiauto platforms. ![]() The Suppressor load features a 45-grain copper-plated round-nose bullet that carries a muzzle velocity of 934 fps. Each load was also fired without any malfunctions through a High Standard Sport King semiauto pistol to measure functionalityįederal Premium’s American Eagle Rimfire Suppressor load features clean-burning propellants that won’t unduly dirty the baffles in a suppressor. None of the loads had any feeding or functionality issues in the semiauto platform. Velocity was measured at 10 yards with a Competition Electronics chronograph. Testing was conducted with a Ruger 10/22 semiautomatic rifle and a Simmons 3-9x32mm scope. We tested each load at 30 yards from a bench, firing five, five-shot groups per load and measuring groups with a digital caliper. So whether you’re looking to thin the herd of lawn-destroying gophers without alarming your neighbors, or if you simply need a low-noise alternative that helps protect your hearing while shooting, here’s a look at five of the best subsonic. 22LR cartridges are typically more accurate than their high-speed counterparts. Also, as many a competition shooter can tell you, subsonic. The Quiet-22 is still plenty lethal to stop a ravenous squirrel at 20 yards and produces roughly half the noise. Take CCI’s Mini-Mag 40-grain round-nose load, for example, which produces 1,235 fps and 135 foot-pounds (ft-lbs.) of energy, and compare it to CCI’s Quiet-22, which slows to 710 fps and 45 ft-lbs. Where subsonic ammo excels, however, is with the. Despite what you might think, much of the noise comes from the gas escaping the barrel, so subsonic rounds aren’t exactly whisper quiet, which is why many add a suppressor to the mix. The tradeoff is less energy on target, which makes going subsonic less desirable with many large hunting calibers. Since the crack of a bullet breaking the sound barrier greatly increases noise, subsonic ammo is designed to leave the muzzle at less than the speed of sound, which is roughly 1,125 fps at sea level. ![]() The truth is, there’s a time to slow things down and keep it quiet, which is why subsonic ammo exists. ![]() Not only is all that velocity-crazed volume hard on the eardrums, it’s also unfriendly to the pocket book, as anyone who has recently bought a box of ammunition for one of the newest long-range super cartridges can tell you. Just stand next to a muzzlebraked magnum or a straight-piped hot rod to get the picture. The drawback, however, is the noise pollution that accompanies our fixation with speed. From muscle cars to overbore rifle cartridges that burn barrels and launch bullets downrange at well beyond 3,000 feet per second (fps), we operate on the assumption that faster is better. As red-blooded Americans, we’ve long ago come to embrace our ancestral need for speed. ![]() ![]() ![]() ![]() Magnetic resonance imaging (MRI) of the spine with and without contrast revealed a syrinx of the conus medullaris without other abnormalities (Fig. Genetic counseling was pursued, and the patient’s parents declined additional familial karyotyping. The deletion extended from band 10q26.11 to 10q26.3, comprising 112 genes including 62 OMIM genes (Supplementary Table 1). Prior microarray analysis as a neonate had shown a 14.34 Mb terminal deletion of chromosome 10q. She had multiple congenital abnormalities including micrognathia, glossoptosis, and airway obstruction characteristic of PRS, as well as cleft palate, strabismus, patent ductus arteriosus, mild dilation of the aortic sinuses, clinodactyly of the fifth finger, and syndactyly involving the bilateral second and third toes. Medical history included premature birth at 31 weeks with grade I intraventricular hemorrhage. ![]() Neurological examination was notable for diffuse hypotonia and global developmental delay, but without focal deficit, incontinence, or prior urinary tract infections. We additionally report a case of a PRS patient presenting with tethered cord and lumbar syrinx in the setting of chromosome 10q terminal deletion.Ī 6-month-old female with a history of PRS was found to have a sacral dimple during a routine outpatient checkup. We thus performed a systematic review of spinal disease in patients with PRS. The molecular genetic and clinical characteristics of spinal disease in PRS remain poorly characterized. Spinal pathologies have rarely been reported in association with PRS, often co-occurring with other congenital anomalies. PRS is most commonly associated with hearing loss, dysmorphic facial features, global developmental delay/intellectual disability, and/or congenital heart defects. Approximately 50% of PRS cases are isolated (non-syndromic), while the remainder are associated with additional anomalies such as a genetic or acquired syndrome. The reported incidence varies widely with an approximate occurrence of 1 in 8500 to 14,000 births. The Pierre Robin sequence (PRS), also known as Robin sequence, is a pattern of congenital facial abnormalities comprising micrognathia, glossoptosis, and airway obstruction. ![]() |
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